Sherry Chandler

From an op-ed in the Washington Post by Alan I. Leshner, chief executive of the American Association for the Advancement of Science and executive publisher of the journal Science, and James A. Thomson, professor of anatomy at the University of Wisconsin School of Medicine and Public Health.

A new way to trick skin cells into acting like embryos changes both everything and nothing at all. Being able to reprogram skin cells into multipurpose stem cells without harming embryos launches an exciting new line of research. It’s important to remember, though, that we’re at square one, uncertain at this early stage whether souped-up skin cells hold the same promise as their embryonic cousins do.

Far from vindicating the current U.S. policy of withholding federal funds from many of those working to develop potentially lifesaving embryonic stem cells, recent papers in the journals Science and Cell described a breakthrough achieved despite political restrictions. In fact, work by both the U.S. and Japanese teams that reprogrammed skin cells depended entirely on previous embryonic stem cell research.

…

the recent tandem advances in the United States and by Shinya Yamanaka’s team in Japan are far from being a Holy Grail, as Charles Krauthammer inaccurately described them. Though potential landmarks, these studies are only a first step on the long road toward eventual therapies.

Krauthammer’s central argument — that the president’s misgivings about embryonic stem cell research inspired innovative alternatives — is fundamentally flawed, too. Yamanaka was of course working in Japan, and scientists around the world are pursuing the full spectrum of options, in many cases faster than researchers in the United States.

This op-ed goes on to point out that strategies that work in the mouse often fail in humans, so it’s a bit too early to celebrate or to congratulate Mr. Bush for saving human embryos (those fertilized eggs that are destined to be thrown in the trash anyway).

Discomfort with the notion of extracting stem cells from embryos is understandable. But many of the life-changing medical advances of recent history, including heart transplantation, have provoked discomfort. Struggling with bioethical questions remains a critical step in any scientific advancement.

A solution that might be more comfortable for many people already exists but cannot be pursued unless the Stem Cell Research Enhancement Act becomes law. Some percentage of the hundreds of thousands of frozen embryos from fertility clinics will eventually be destroyed. American couples meanwhile are not being given the choice to donate their frozen embryos to federal research to help others through stem cell advances.

It remains to be seen whether reprogrammed skin cells will differ in significant ways from embryonic stem cells. We remain hopeful, but it’s too early to say we’re certain.

We hope Congress will override the president’s veto of the Stem Cell Research Enhancement Act. Further delays in pursuing the clearly viable option of embryonic stem cells will result in an irretrievable loss of time, especially if the new approach fails to prove itself.

It’s a morning for sound.

I See Invisible People gives us the sound of a Croatian Sea Organ. This giant pipe organ played by the lapping of the waves in Zadar, Croatia, is the creation of architect Nikola Basic. National Geographic has a video.

Heraclitean Fire provides a link to the Bitish Library recordings of English Accents and Dialects, in this case a man from Somerset talking about making cider.

David Caddy, of course, provides a sampling of a contemporary Dorset accent doing poetic commentary at So Here We Are. His latest deals with the Scots poet Thomas A. Clark.

David also participates in Middle Ditch, the ongoing saga of English village life.

And the Lipstick of Noise is all about poetry as an aural experience.

Oh! and this has nothing to do with sound by Pocahontas County Fare provides a neat link to a reading list of British Women’s Novels, 1775-1818 . If you like old Gothic novels, like Ann Radcliffe’s The Mysteries of Udolpho, this site will lead you to more of the same, often with a link to full text.